A neuron running out of energy

ATP shortage

Enjoyed the presentation in front of a real audience for the first time in 1.5 years! Neuroscience Frontier Symposium@The 62nd Annual Meeting of the Japanese Society of Neurology Here is a back-up movie prepared for 100% virtual meeting:

Phase transitions in the cytoplasm in a van Gogh style


ゼブラフィッシュ自由形/Freestyle swimming zebrafish

3 day-old zebrafish larva/生後三日目のゼブラフィッシュ仔魚

Distancing in the zebrafish lab


Zebrafish researcher / ゼブラフィッシュ研究者

ouwojima / ウヲジマ(魚縞)

Fast-forwarding of Motor Neuron Degeneration by Optogenetics


TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun 11, 1004 (2020).

Zebrafish streamer / 水道橋ゼブラ駿河台

Modified from Carp streamer by Hiroshige

Protein aggregation in the Japanese style

Optogenetic ALS fish (right)


Click here for the movie (動画はこちらから).

For details (詳しくは): https://www.biorxiv.org/content/10.1101/789057v1

2019 Gordon Research Conference: Amyotrophic Lateral Sclerosis (ALS) and Related Motor Neuron Diseases @ Mount Snow

Selected for oral presentation
Mount Snow

Start(le) of New Era, REIWA(令和)

3 day-old zebrafish are relatively insensitive to touch but able to startle against vibration1-5827

A zebrafish model of Jim Carrey (The Mask)


A magical mask that transforms zebrafish head

Be patient.

Fishing attitude of live imaging

Extraocular muscle and Kabuki kumadori


Both extraocular muscles and Kabuki make-up kumadori support dynamic eye movements. 
Click here for our paper Asakawa et al., 2012 Dev Dyn.
Tg[mnr2b-EGFP] Tg[hspGFFDMC131B] Tg[UAS:RFP] larva


Body movements of zebrafish embryos at 24 hours post-fertilization

The Ophthalmologist featured our recent paper! “An Abnormal Connection

Ophthalmologist, 2018.09.16

2018. 8. 7.  Our work has just been published in Cell Reports!

静岡新聞・2018.08.07. 朝刊


Mona Lisa is staring at you (by the action of abducens motor neurons)

脳から伸びる外転神経に含まれる運動ニューロン(緑)が、筋肉(外転筋、マゼンタ)を収縮させると、眼球が外側に回転する。Abducens motor neurons (green) rotates the eye globe outward by contracting the lateral rectus muscle (magenta).

雪に耐えて梅花麗し (Beautiful plum blossoms have experienced a severe winter.)

Neuromuscular synapses were finally visualized in a live zebrafish larva after many trials and errors

生きた運動ニューロン(緑)と筋肉(マゼンタ、アセチルコリン受容体)とのシナプスの初めての写真。 My first picture of neuromuscular synapses in a live zebrafish: Motor neurons (green) and acetylecholine receptors (magenta)

Behind the Great Wave and Great Fish


Abducens motor neurons (green) and extraocular muscles (magenta) in a live zebrafish larva.

Abducens motor neurons (green) and extraocular muscles (magenta) in a live zebrafish larva.

Arguably the world’s most famous outward eye movement (abduction) generated by pieces of zebrafish

Mona Lisa made of zebrafish

せりか基金賞 授賞式